Abstract

Article info 2016 4 (1)    004  (01)   pp.  1 ~ 17
Title Natural products targeting STAT3 signaling pathways in cancer cells
Authors Yena Jin1,2, Younghwan Kim1, Yu-Jin Lee1, Dong Cho Han1,2 and Byoung-Mog Kwon1,2,*
Institutions 1Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology, 2University of Science and Technology in Korea, 125 Gwahakro Yoosunggu, Daejeon 34141, Republic of Korea. *Correspondence: kwonbm@kribb.re.kr
Abstract Cancer is a leading cause of death worldwide. The roles and significance of Signal Transducer and Activator of Transcription 3 (STAT3) in human cancers have been extensively studied. STAT3 is a promising therapeutic target for cancer drug discovery. Herbal medicine-derived secondary metabolites efficiently impact all cancer hallmarks; therefore, natural products are a major source of new cancer drug development. Many natural products can inhibit STAT signaling pathways in cancer cells by targeting different pathways. In this review, we describe the structures of STAT3 inhibitors isolated from herbal medicines and discuss their targeting molecules and modes of action.