Abstract

Article info 2016 4 (4)    004  (04)   pp.  89 ~ 97
Title Molecular aspects of CEP55 during cytokinesis and tumorigenesis
Authors Kyungjin Min and Hyung Ho Lee*
Institutions Department of Chemistry, College of Natural Sciences, Seoul National University, Seoul 08826, Korea. *Correspondence: hyungholee@snu.ac.kr
Abstract Cytokinesis is the last stage of the cell cycle, in which the cytoplasm of parental cell is divided into two daughter cells. During cytokinesis, a special region called midbody forms between the two daughter cells. One of the key midbody proteins, a centrosomal protein of 55 kDa (CEP55) is a pivotal regulator of cytokinesis. CEP55 interacts with ALIX/ endosomal sorting complex required for transport (ESCRT) complexes, which are known as membrane scissors for cytokinesis. To perform its function at the midbody, CEP55 is recruited to the midbody from the centrosome and its mislocalization leads to a failure of cell division. Beyond that, CEP55 performs a wide variety of functions, including modulation of midbody fate via the interaction with the autophagic receptor (NBR1) protein. CEP55 is also well known as an oncogenic protein and its overexpression is related to many cancers, including those of the breast, lung, colon, liver, and brain. CEP55 is related to cancer progression, including metastasis, angiogenesis, and proliferation, involving PI3K/ AKT or AKT/mTOR pathways. In this review, we present the emerging roles of CEP55 as an oncogene by focusing on the molecular aspects of CEP55.