Abstract

Article info 2018 6 (1)    006  (01)   pp.  1 ~ 9
Title Structural aspects of EF-hand containing calcium buffers, sensors, and S100 family
Authors Jihyeong Yang and Soo Hyun Eom*
Institutions 1School of Life Sciences, Gwangju Institiute of Science and Technology (GIST), 123 Cheomdan-gwagiro, Buk-gu, Gwangju 61005, Republic of Korea. *Correspondence: eom@gist.ac.kr
Abstract The EF-hand motif is one of the common calcium binding motifs, and the protein family containing this motif plays an essential role in the regulating all aspects of cellular processes. The EF-hand motif is a helix-loop-helix structure and the canonical EF-hand chelates Ca2+ by seven ligands in the loop with pentagonal bipyramid geometry. Many high-resolution structures of EF-hand containing calcium binding proteins (CaBPS), as well as the complex with target proteins, have been identified. They exhibit a various loop composition and structure and they affect a great diversity of target interaction and functions. In this review, structural details of the EF-hand motif are discussed to understand the Ca2+ binding mechanism, Ca2+-induced conformational change in EF-hand CaBPS, and the diversity of their complex with their target molecules.